Osteogenesis Imperfecta Essay -- Disease, Disorders

Osteogenesis imperfecta (OI), withal known as brittle bone disease, is a ancient genetic disorder with the main characteristic being that the bones last very easily, usually for no apparent reason. The major cause of osteogenesis imperfecta is a mutation in the genes that produce collagen. Collagen is the main protein that works toward the production of connecter tissue. Individuals with this disorder forget produce less collagen than needed, which causes the bone development to be endangered. This could result in bone deformities. There are four casefuls of osteogenesis imperfecta, and in all four types you will see bone discretion with quintuple fractures and bone deformities.Type I of OI is the most common, comprising 70% of all cases. contuse will occur very easily in this type. The bone fragility is considered mild to moderate, and osteoporosis will be present. In this case it is likely that threefold fractures will have occurred before the age of 5.Type II of OI accou nts for nearly 10% of all cases. OI Type II is always lethal in the fetus. This is the most grave form of OI. The ribs will be thin, there will be limited cranial and facial bone ossification, and the limbs will be short.Type III of OI makes up 15% of all cases. This is the next in severity after Type II, and the type most known to radiologists and orthopedical surgeons. Two-thirds of these cases will have fractures at birth. There will be severe bone fragility with multiple fractures and deformity that will be progressive. Children with this type seem to have severe dwarfism due to spinal condensate fractures and disturbance in growth plates.Type IV of OI is much rarer, comprising moreover 5% of cases. The bones may appear normal at the measure of the first... ... law enforcement and legal counsel will be involved. It may also be necessary to contact a child psychologist or separate therapist to assist.Works CitedChapter 37. Operative Techniques in Orthopaedic Surgery. Ed. Sam Wiesel. quaternary ed. Vol. 2. Lippincott Williams & Wilkins, 2011. eBook.Hoffmeister, Ellen. Gene Therapy and Pharmaceuticals Offer Hope for Many Patients With Brittle Bones. Bone and say 11.5 (2005) 49-51. eBook.Kaiser, L. R., A. C. O. Surgeons, and W. H. Pearce. Acs surgery, principles & practice. 6th. Webmd Prof Pub, 2007. eBook.McMillan, Julia A., Ralph D. Feigin, Catherine DeAngelis, and M. Douglas Jones. Oskis Pediatrics, Principles & Practice. Williams & Wilkins, 2006.Minor, Patricia. Living with OI One Day at a Time. retire America, 2006. Web.Picoult, Jodi. Handle With Care. New York, NY, USA Washington Square Press, 2009